AUTOMATED TABLET DROP & SAMPLING
The first procedure at the start of any dissolution run is to drop the samples into the individual vessels.
This function can, of course, be performed manually if desired: indeed, when using the Copley range of Tablet Dissolution Testers, this is relatively easy since the baths have been deliberately designed to reduce ‘clutter’ and maximise visibility and access in the critical sampling area above the water bath.
This does mean, of course, employing a ‘staggered’ start since it is very difficult to introduce all the samples simultaneously manually. For this reason, a correction factor has to be applied to the final results in order to take into account the ‘time-lag’ between introducing the samples.
In order to obviate this problem, the Dissolution Tester Model DIS 8000 can be fitted with an automatic ‘tablet drop’ system.
In this system, the tablets are placed in a series of chambers on the dissolution vessel lids and ejected into the vessels simultaneously by depressing a button.
SAMPLING
Five different dissolution sampling systems are available according to the user requirements.
The simplest method is to sample each vessel using a manual sampling cannula. The manual sampling cannula that we supply has an all 316 stainless steel Luer fitting and is bent through 90 degrees at the top for easy positioning in the dissolution vessel.
Alternatively, we can offer a set of 8 resident probes designed to fit directly into the dissolution lid.
The probes can be used in three ways:
- With luer fittings for manual sampling of each individual vessel
- In conjunction with the manual sampling manifold, again for manual sampling via a syringe, but with improved accessibility
- In conjunction with the return line inserts for use with automated systems
Finally, we can offer a motorised sampling manifold.
This manifold ensures that the sampling probes are only introduced into the test media during sampling thus eliminating any hydrodynamic disturbances which may in some cases influence the test results.
The motorised sampling manifold is fitted with a simple contact closure for incorporation into automated system or operated manually via a push button or foot switch.
For more information: 